Drug interactions
Ipratropium-salbutamol + Sotalol
Severity: Major
Ipratropium-salbutamol and Sotalol: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotalol is a non-selective beta-blocker that antagonizes the bronchodilating effect of salbutamol and may provoke bronchospasm in asthma or COPD. Both drugs also affect QT and potassium, raising the risk of torsades de pointes when salbutamol causes hypokalemia.
What this interaction means in plain words
Ipratropium-salbutamol and Sotalol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ipratropium-salbutamol belongs to Respiratory; Sotalol belongs to Cardiovascular.
Why it happens
Pharmacodynamic antagonism at beta2-receptors plus additive QT prolongation and beta-agonist-induced hypokalemia.
What to do
Avoid sotalol in patients with significant reactive airway disease needing salbutamol; consider an alternative antiarrhythmic. If used together, monitor ECG, potassium and magnesium and assess bronchodilator response.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Ipratropium-salbutamol
Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Frequently asked questions
Can I take Ipratropium-salbutamol with Sotalol?
MediHelp rates the interaction as major. Ipratropium-salbutamol and Sotalol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Sotalol is a non-selective beta-blocker that antagonizes the bronchodilating effect of salbutamol and may provoke bronchospasm in asthma or COPD. Both drugs also affect QT and potassium, raising the risk of torsades de pointes when salbutamol causes hypokalemia.
How serious is the interaction between Ipratropium-salbutamol and Sotalol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid sotalol in patients with significant reactive airway disease needing salbutamol; consider an alternative antiarrhythmic. If used together, monitor ECG, potassium and magnesium and assess bronchodilator response.
What other medicines interact with Ipratropium-salbutamol?
MediHelp also lists interactions of Ipratropium-salbutamol with, for example, Amisulpride, Arsenic trioxide, Carvedilol. The full list is on the Ipratropium-salbutamol page.
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