Drug interactions
Ipratropium-salbutamol + Trimipramine
Severity: Moderate
Ipratropium-salbutamol and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trimipramine can potentiate the cardiovascular effects of salbutamol, causing tachycardia, arrhythmias or blood pressure changes. Trimipramine also has QT-prolonging and anticholinergic properties that may add to the effects of the combination product.
What this interaction means in plain words
Ipratropium-salbutamol and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ipratropium-salbutamol belongs to Respiratory; Trimipramine belongs to Central Nervous System.
Why it happens
Tricyclic inhibition of noradrenaline reuptake together with beta-2 agonist stimulation gives additive adrenergic and arrhythmogenic effects.
What to do
Monitor heart rate, blood pressure and ECG in patients with cardiac disease, and keep salbutamol at the lowest effective dose. Watch for urinary retention or dry mouth from additive anticholinergic effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ipratropium-salbutamol and Trimipramine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Ipratropium-salbutamol
Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Ipratropium-salbutamol with Trimipramine?
MediHelp rates the interaction as moderate. Ipratropium-salbutamol and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trimipramine can potentiate the cardiovascular effects of salbutamol, causing tachycardia, arrhythmias or blood pressure changes. Trimipramine also has QT-prolonging and anticholinergic properties that may add to the effects of the combination product.
How serious is the interaction between Ipratropium-salbutamol and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and ECG in patients with cardiac disease, and keep salbutamol at the lowest effective dose. Watch for urinary retention or dry mouth from additive anticholinergic effects.
What other medicines interact with Ipratropium-salbutamol?
MediHelp also lists interactions of Ipratropium-salbutamol with, for example, Amisulpride, Arsenic trioxide, Carvedilol. The full list is on the Ipratropium-salbutamol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
