Drug interactions
Irbesartan + Metolazone
Severity: Moderate
Irbesartan and Metolazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Together they lower blood pressure additively and may cause hypotension or worsened renal function in volume-depleted patients. The ARB's potassium-retaining effect partly counters thiazide-induced potassium loss.
What this interaction means in plain words
Irbesartan and Metolazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Irbesartan belongs to Cardiovascular; Metolazone belongs to Cardiovascular.
Why it happens
Additive blood pressure lowering; diuretic volume depletion increases dependence of glomerular filtration on angiotensin II.
What to do
Monitor blood pressure, serum creatinine and potassium after starting or adjusting either drug, and correct volume depletion first.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metolazone
Other interactions of Irbesartan
- Aliskiren + Irbesartan Contraindicated
- Irbesartan + Sparsentan Contraindicated
- Amifostine + Irbesartan Major
- Amiloride + Irbesartan Major
- Amlodipine-benazepril + Irbesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Irbesartan Major
Frequently asked questions
Can I take Irbesartan with Metolazone?
MediHelp rates the interaction as moderate. Irbesartan and Metolazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Together they lower blood pressure additively and may cause hypotension or worsened renal function in volume-depleted patients. The ARB's potassium-retaining effect partly counters thiazide-induced potassium loss.
How serious is the interaction between Irbesartan and Metolazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium after starting or adjusting either drug, and correct volume depletion first.
What other medicines interact with Metolazone?
MediHelp also lists interactions of Metolazone with, for example, Amifostine, Amlodipine-hydrochlorothiazide-valsartan, Amlodipine-olmesartan-hydrochlorothiazide. The full list is on the Metolazone page.
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