Drug interactions
Irbesartan + Vadadustat
Severity: Minor
Irbesartan and Vadadustat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Irbesartan may inhibit renal and hepatic organic anion transporters and could raise vadadustat exposure. Higher exposure could cause an excessive rise in hemoglobin and increase adverse effects.
What this interaction means in plain words
Irbesartan and Vadadustat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Irbesartan belongs to Cardiovascular; Vadadustat belongs to Endocrine.
Why it happens
Possible inhibition of OAT1/OAT3 transport reduces vadadustat clearance, though the evidence for irbesartan is limited.
What to do
Monitor hemoglobin regularly and adjust vadadustat dose according to labeling if the rise is too rapid.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Irbesartan
- Aliskiren + Irbesartan Contraindicated
- Irbesartan + Sparsentan Contraindicated
- Amifostine + Irbesartan Major
- Amiloride + Irbesartan Major
- Amlodipine-benazepril + Irbesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Irbesartan Major
Other interactions of Vadadustat
- Atorvastatin + Vadadustat Moderate
- Balsalazide + Vadadustat Moderate
- Baricitinib + Vadadustat Moderate
- Benzathine penicillin g + Vadadustat Moderate
- Calcium carbonate + Vadadustat Moderate
- Calcium + Vadadustat Moderate
Frequently asked questions
Can I take Irbesartan with Vadadustat?
MediHelp rates the interaction as minor. Irbesartan and Vadadustat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Irbesartan may inhibit renal and hepatic organic anion transporters and could raise vadadustat exposure. Higher exposure could cause an excessive rise in hemoglobin and increase adverse effects.
How serious is the interaction between Irbesartan and Vadadustat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor hemoglobin regularly and adjust vadadustat dose according to labeling if the rise is too rapid.
What other medicines interact with Irbesartan?
MediHelp also lists interactions of Irbesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Irbesartan page.
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