Drug interactions
Irinotecan + Momelotinib
Severity: Moderate
Irinotecan and Momelotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Momelotinib inhibits BCRP, a transporter that clears irinotecan's active metabolite SN-38. Higher SN-38 exposure may increase diarrhea and neutropenia.
What this interaction means in plain words
Irinotecan and Momelotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Irinotecan belongs to Oncology; Momelotinib belongs to Oncology.
Why it happens
Momelotinib inhibits BCRP efflux transport, which may increase exposure to SN-38 and irinotecan.
What to do
Monitor blood counts and bowel function, and reduce the irinotecan dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Irinotecan
- Clozapine + Irinotecan Contraindicated
- Irinotecan + Sacituzumab govitecan Contraindicated
- Adenovirus types 4 and 7 live + Irinotecan Major
- Apalutamide + Irinotecan Major
- Atazanavir + Irinotecan Major
- Carbamazepine + Irinotecan Major
Other interactions of Momelotinib
- Atorvastatin + Momelotinib Moderate
- Clarithromycin + Momelotinib Moderate
- Cyclosporin + Momelotinib Moderate
- Daunorubicin + Momelotinib Moderate
- Erythromycin + Momelotinib Moderate
- Fluvastatin + Momelotinib Moderate
Frequently asked questions
Can I take Irinotecan with Momelotinib?
MediHelp rates the interaction as moderate. Irinotecan and Momelotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Momelotinib inhibits BCRP, a transporter that clears irinotecan's active metabolite SN-38. Higher SN-38 exposure may increase diarrhea and neutropenia.
How serious is the interaction between Irinotecan and Momelotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and bowel function, and reduce the irinotecan dose if toxicity develops.
What other medicines interact with Irinotecan?
MediHelp also lists interactions of Irinotecan with, for example, Clozapine, Sacituzumab govitecan, Adenovirus types 4 and 7 live. The full list is on the Irinotecan page.
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