Drug interactions
Iron + Manganese
Severity: Minor
Iron and Manganese: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iron and manganese share intestinal absorption pathways, so high doses of oral iron can reduce manganese absorption. This is mainly of concern with long-term supplementation in people with marginal manganese intake.
What this interaction means in plain words
Iron and Manganese have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Iron belongs to Gastrointestinal Tract; Manganese belongs to Gastrointestinal Tract.
Why it happens
Competition for the shared divalent metal transporter DMT1 in the intestine.
What to do
No routine action is needed. Separate supplement doses by a few hours if long-term use of both is planned.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Iron
- Acetohydroxamic acid + Iron Moderate
- Aluminum hydroxide + Iron Moderate
- Baloxavir marboxil + Iron Moderate
- Calcium acetate + Iron Moderate
- Calcium carbonate + Iron Moderate
- Calcium citrate + Iron Moderate
Other interactions of Manganese
- Delafloxacin + Manganese Moderate
- Manganese + Omadacycline Moderate
- Manganese + Sarecycline Moderate
- Baloxavir marboxil + Manganese Minor
- Calcium acetate + Manganese Minor
- Calcium carbonate + Manganese Minor
Frequently asked questions
Can I take Iron with Manganese?
MediHelp rates the interaction as minor. Iron and Manganese have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Iron and manganese share intestinal absorption pathways, so high doses of oral iron can reduce manganese absorption. This is mainly of concern with long-term supplementation in people with marginal manganese intake.
How serious is the interaction between Iron and Manganese?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed. Separate supplement doses by a few hours if long-term use of both is planned.
What other medicines interact with Iron?
MediHelp also lists interactions of Iron with, for example, Acetohydroxamic acid, Aluminum hydroxide, Baloxavir marboxil. The full list is on the Iron page.
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