Drug interactions
Manganese + Sarecycline
Severity: Moderate
Manganese and Sarecycline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral manganese can bind sarecycline in the gut and lower its absorption, which may reduce efficacy in acne treatment.
What this interaction means in plain words
Manganese and Sarecycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Manganese belongs to Gastrointestinal Tract; Sarecycline belongs to Anti Bacterial.
Why it happens
Multivalent cations chelate tetracyclines in the gastrointestinal tract, reducing absorption.
What to do
Separate sarecycline from manganese-containing supplements by at least 2 to 3 hours.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Manganese
- Delafloxacin + Manganese Moderate
- Manganese + Omadacycline Moderate
- Baloxavir marboxil + Manganese Minor
- Calcium acetate + Manganese Minor
- Calcium carbonate + Manganese Minor
- Calcium chloride + Manganese Minor
Other interactions of Sarecycline
- Acitretin + Sarecycline Contraindicated
- Isotretinoin + Sarecycline Major
- Sarecycline + Tretinoin Major
- Aluminum hydroxide + Sarecycline Moderate
- Calcium carbonate + Sarecycline Moderate
- Calcium + Sarecycline Moderate
Frequently asked questions
Can I take Manganese with Sarecycline?
MediHelp rates the interaction as moderate. Manganese and Sarecycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral manganese can bind sarecycline in the gut and lower its absorption, which may reduce efficacy in acne treatment.
How serious is the interaction between Manganese and Sarecycline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate sarecycline from manganese-containing supplements by at least 2 to 3 hours.
What other medicines interact with Manganese?
MediHelp also lists interactions of Manganese with, for example, Delafloxacin, Omadacycline, Baloxavir marboxil. The full list is on the Manganese page.
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