Drug interactions
Calcium carbonate + Manganese
Severity: Minor
Calcium carbonate and Manganese: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcium can reduce intestinal absorption of manganese, and the reverse may occur through competition. Clinical significance is small for most people.
What this interaction means in plain words
Calcium carbonate and Manganese have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Calcium carbonate belongs to Gastrointestinal Tract; Manganese belongs to Gastrointestinal Tract.
Why it happens
Competition for shared divalent cation absorption pathways in the gut.
What to do
Take the two supplements at least 2 hours apart.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Calcium carbonate
Other interactions of Manganese
- Delafloxacin + Manganese Moderate
- Manganese + Omadacycline Moderate
- Manganese + Sarecycline Moderate
- Baloxavir marboxil + Manganese Minor
- Calcium acetate + Manganese Minor
- Calcium chloride + Manganese Minor
Frequently asked questions
Can I take Calcium carbonate with Manganese?
MediHelp rates the interaction as minor. Calcium carbonate and Manganese have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Calcium can reduce intestinal absorption of manganese, and the reverse may occur through competition. Clinical significance is small for most people.
How serious is the interaction between Calcium carbonate and Manganese?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take the two supplements at least 2 hours apart.
What other medicines interact with Calcium carbonate?
MediHelp also lists interactions of Calcium carbonate with, for example, Acalabrutinib, Alendronate, Amlodipine-hydrochlorothiazide-valsartan. The full list is on the Calcium carbonate page.
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