Drug interactions
Delafloxacin + Manganese
Severity: Moderate
Delafloxacin and Manganese: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral manganese can bind delafloxacin in the gut, reducing its absorption and potentially causing subtherapeutic antibiotic levels and treatment failure.
What this interaction means in plain words
Delafloxacin and Manganese can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Delafloxacin belongs to Anti Bacterial; Manganese belongs to Gastrointestinal Tract.
Why it happens
Divalent metal cations chelate fluoroquinolones in the gastrointestinal tract, reducing absorption.
What to do
Give oral delafloxacin at least 2 hours before or 6 hours after manganese-containing products.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Manganese
- Manganese + Omadacycline Moderate
- Manganese + Sarecycline Moderate
- Baloxavir marboxil + Manganese Minor
- Calcium acetate + Manganese Minor
- Calcium carbonate + Manganese Minor
- Calcium chloride + Manganese Minor
Other interactions of Delafloxacin
- Aluminum hydroxide + Delafloxacin Moderate
- Calcium carbonate + Delafloxacin Moderate
- Calcium + Delafloxacin Moderate
- Carbonyl iron + Delafloxacin Moderate
- Delafloxacin + Didanosine Moderate
- Delafloxacin + Ferrous fumarate Moderate
Frequently asked questions
Can I take Delafloxacin with Manganese?
MediHelp rates the interaction as moderate. Delafloxacin and Manganese can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral manganese can bind delafloxacin in the gut, reducing its absorption and potentially causing subtherapeutic antibiotic levels and treatment failure.
How serious is the interaction between Delafloxacin and Manganese?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give oral delafloxacin at least 2 hours before or 6 hours after manganese-containing products.
What other medicines interact with Manganese?
MediHelp also lists interactions of Manganese with, for example, Omadacycline, Sarecycline, Baloxavir marboxil. The full list is on the Manganese page.
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