Drug interactions
Manganese + Omadacycline
Severity: Moderate
Manganese and Omadacycline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral manganese can bind omadacycline in the gut and lower its absorption, which may reduce antibacterial efficacy.
What this interaction means in plain words
Manganese and Omadacycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Manganese belongs to Gastrointestinal Tract; Omadacycline belongs to Anti Bacterial.
Why it happens
Multivalent cations chelate tetracyclines in the gastrointestinal tract, reducing absorption.
What to do
Separate oral omadacycline from manganese-containing supplements by several hours, following labeling advice for tetracyclines and cations.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Manganese
- Delafloxacin + Manganese Moderate
- Manganese + Sarecycline Moderate
- Baloxavir marboxil + Manganese Minor
- Calcium acetate + Manganese Minor
- Calcium carbonate + Manganese Minor
- Calcium chloride + Manganese Minor
Other interactions of Omadacycline
- Acitretin + Omadacycline Contraindicated
- Isotretinoin + Omadacycline Major
- Omadacycline + Tretinoin Major
- Aluminum hydroxide + Omadacycline Moderate
- Amoxicillin-clavulanic acid + Omadacycline Moderate
- Amoxicillin + Omadacycline Moderate
Frequently asked questions
Can I take Manganese with Omadacycline?
MediHelp rates the interaction as moderate. Manganese and Omadacycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral manganese can bind omadacycline in the gut and lower its absorption, which may reduce antibacterial efficacy.
How serious is the interaction between Manganese and Omadacycline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate oral omadacycline from manganese-containing supplements by several hours, following labeling advice for tetracyclines and cations.
What other medicines interact with Manganese?
MediHelp also lists interactions of Manganese with, for example, Delafloxacin, Sarecycline, Baloxavir marboxil. The full list is on the Manganese page.
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