Drug interactions
Isavuconazole + Midazolam
Severity: Moderate
Isavuconazole and Midazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isavuconazole roughly doubles oral midazolam exposure. This can cause prolonged or excessive sedation and respiratory depression.
What this interaction means in plain words
Isavuconazole and Midazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isavuconazole belongs to Anti Fungals; Midazolam belongs to Central Nervous System.
Why it happens
Inhibition of intestinal and hepatic CYP3A4 reduces midazolam first-pass and systemic clearance.
What to do
Monitor sedation level and respiratory status and reduce the midazolam dose if needed, particularly with oral dosing.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isavuconazole
- Carbamazepine + Isavuconazole Contraindicated
- Efavirenz + Isavuconazole Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Isavuconazole + Ketoconazole Contraindicated
- Isavuconazole + Phenobarbitone Contraindicated
- Isavuconazole + Phenytoin Contraindicated
Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Frequently asked questions
Can I take Isavuconazole with Midazolam?
MediHelp rates the interaction as moderate. Isavuconazole and Midazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isavuconazole roughly doubles oral midazolam exposure. This can cause prolonged or excessive sedation and respiratory depression.
How serious is the interaction between Isavuconazole and Midazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation level and respiratory status and reduce the midazolam dose if needed, particularly with oral dosing.
What other medicines interact with Isavuconazole?
MediHelp also lists interactions of Isavuconazole with, for example, Carbamazepine, Efavirenz, Etravirine. The full list is on the Isavuconazole page.
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