Drug interactions
Isavuconazonium + Methylprednisolone
Severity: Moderate
Isavuconazonium and Methylprednisolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isavuconazole, the active moiety, is a moderate CYP3A4 inhibitor and can raise methylprednisolone exposure. Combined corticosteroid immunosuppression also increases the risk of infection in patients treated for fungal disease.
What this interaction means in plain words
Isavuconazonium and Methylprednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isavuconazonium belongs to Anti Fungals; Methylprednisolone belongs to Endocrine.
Why it happens
Isavuconazole inhibits CYP3A4, reducing methylprednisolone metabolism, with additive immunosuppression from the steroid.
What to do
Monitor for corticosteroid adverse effects and consider lowering the methylprednisolone dose if prolonged therapy is needed. Monitor antifungal response and signs of infection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methylprednisolone
- Bcg vaccine live + Methylprednisolone Contraindicated
- Measles mumps and rubella vaccine live + Methylprednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Methylprednisolone Contraindicated
- Measles vaccine + Methylprednisolone Contraindicated
- Methylprednisolone + Mifepristone Contraindicated
- Methylprednisolone + Rubella vaccine Contraindicated
Other interactions of Isavuconazonium
- Amobarbital + Isavuconazonium Contraindicated
- Apalutamide + Isavuconazonium Contraindicated
- Carbamazepine + Isavuconazonium Contraindicated
- Cisapride + Isavuconazonium Contraindicated
- Efavirenz + Isavuconazonium Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
Frequently asked questions
Can I take Isavuconazonium with Methylprednisolone?
MediHelp rates the interaction as moderate. Isavuconazonium and Methylprednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isavuconazole, the active moiety, is a moderate CYP3A4 inhibitor and can raise methylprednisolone exposure. Combined corticosteroid immunosuppression also increases the risk of infection in patients treated for fungal disease.
How serious is the interaction between Isavuconazonium and Methylprednisolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for corticosteroid adverse effects and consider lowering the methylprednisolone dose if prolonged therapy is needed. Monitor antifungal response and signs of infection.
What other medicines interact with Methylprednisolone?
MediHelp also lists interactions of Methylprednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Methylprednisolone page.
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