Drug interactions
Isavuconazonium + Palbociclib
Severity: Moderate
Isavuconazonium and Palbociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isavuconazonium is converted to isavuconazole, a CYP3A4 substrate and moderate inhibitor. Palbociclib is a weak time-dependent CYP3A4 inhibitor, so any rise in isavuconazole levels is likely small. Isavuconazole, in turn, may increase palbociclib exposure.
What this interaction means in plain words
Isavuconazonium and Palbociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isavuconazonium belongs to Anti Fungals; Palbociclib belongs to Oncology.
Why it happens
Isavuconazole inhibits CYP3A4, reducing palbociclib clearance, and palbociclib weakly inhibits CYP3A4.
What to do
Monitor blood counts for neutropenia and consider reducing the palbociclib dose if toxicity develops. Monitor for isavuconazole adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Isavuconazonium and Palbociclib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Palbociclib
Other interactions of Isavuconazonium
- Amobarbital + Isavuconazonium Contraindicated
- Apalutamide + Isavuconazonium Contraindicated
- Carbamazepine + Isavuconazonium Contraindicated
- Cisapride + Isavuconazonium Contraindicated
- Efavirenz + Isavuconazonium Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
Frequently asked questions
Can I take Isavuconazonium with Palbociclib?
MediHelp rates the interaction as moderate. Isavuconazonium and Palbociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isavuconazonium is converted to isavuconazole, a CYP3A4 substrate and moderate inhibitor. Palbociclib is a weak time-dependent CYP3A4 inhibitor, so any rise in isavuconazole levels is likely small. Isavuconazole, in turn, may increase palbociclib exposure.
How serious is the interaction between Isavuconazonium and Palbociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts for neutropenia and consider reducing the palbociclib dose if toxicity develops. Monitor for isavuconazole adverse effects.
What other medicines interact with Palbociclib?
MediHelp also lists interactions of Palbociclib with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Palbociclib page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
