Drug interactions
Isavuconazonium + Trazodone
Severity: Moderate
Isavuconazonium and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isavuconazole, the active form of isavuconazonium, is a moderate CYP3A4 inhibitor and can raise trazodone concentrations. This increases the risk of sedation, hypotension, and QT prolongation from trazodone.
What this interaction means in plain words
Isavuconazonium and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isavuconazonium belongs to Anti Fungals; Trazodone belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4 metabolism of trazodone by isavuconazole.
What to do
Consider a lower trazodone dose and monitor for sedation and dizziness. Obtain an ECG if other QT-prolonging drugs are used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Other interactions of Isavuconazonium
- Amobarbital + Isavuconazonium Contraindicated
- Apalutamide + Isavuconazonium Contraindicated
- Carbamazepine + Isavuconazonium Contraindicated
- Cisapride + Isavuconazonium Contraindicated
- Efavirenz + Isavuconazonium Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
Frequently asked questions
Can I take Isavuconazonium with Trazodone?
MediHelp rates the interaction as moderate. Isavuconazonium and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isavuconazole, the active form of isavuconazonium, is a moderate CYP3A4 inhibitor and can raise trazodone concentrations. This increases the risk of sedation, hypotension, and QT prolongation from trazodone.
How serious is the interaction between Isavuconazonium and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a lower trazodone dose and monitor for sedation and dizziness. Obtain an ECG if other QT-prolonging drugs are used.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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