Drug interactions
Isavuconazonium + Zileuton
Severity: Minor
Isavuconazonium and Zileuton: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zileuton is a weak CYP3A4 inhibitor and isavuconazole, the active moiety of isavuconazonium, is a CYP3A4 substrate. Exposure to isavuconazole may rise modestly, though the effect is expected to be small.
What this interaction means in plain words
Isavuconazonium and Zileuton have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Isavuconazonium belongs to Anti Fungals; Zileuton belongs to Respiratory.
Why it happens
Weak inhibition of CYP3A4-mediated metabolism of isavuconazole by zileuton.
What to do
No routine dose change is needed; watch for isavuconazole adverse effects such as liver enzyme elevation and QT shortening if clinical signs appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Zileuton
- Fezolinetant + Zileuton Contraindicated
- Pimozide + Zileuton Contraindicated
- Alosetron + Zileuton Major
- Clozapine + Zileuton Major
- Lomitapide + Zileuton Major
- Lonafarnib + Zileuton Major
Other interactions of Isavuconazonium
- Amobarbital + Isavuconazonium Contraindicated
- Apalutamide + Isavuconazonium Contraindicated
- Carbamazepine + Isavuconazonium Contraindicated
- Cisapride + Isavuconazonium Contraindicated
- Efavirenz + Isavuconazonium Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
Frequently asked questions
Can I take Isavuconazonium with Zileuton?
MediHelp rates the interaction as minor. Isavuconazonium and Zileuton have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Zileuton is a weak CYP3A4 inhibitor and isavuconazole, the active moiety of isavuconazonium, is a CYP3A4 substrate. Exposure to isavuconazole may rise modestly, though the effect is expected to be small.
How serious is the interaction between Isavuconazonium and Zileuton?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; watch for isavuconazole adverse effects such as liver enzyme elevation and QT shortening if clinical signs appear.
What other medicines interact with Zileuton?
MediHelp also lists interactions of Zileuton with, for example, Fezolinetant, Pimozide, Alosetron. The full list is on the Zileuton page.
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