Drug interactions
Isocarboxazid + Metoclopramide
Severity: Major
Isocarboxazid and Metoclopramide: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoclopramide has been reported to release catecholamines and may provoke a pressor response, which could be exaggerated in patients taking MAO inhibitors. Combined serotonergic and dopaminergic effects may also add risk of neurological toxicity.
What this interaction means in plain words
Isocarboxazid and Metoclopramide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Isocarboxazid belongs to Central Nervous System; Metoclopramide belongs to Gastrointestinal Tract.
Why it happens
Metoclopramide-related catecholamine release with MAO inhibition may increase pressor effects, plus possible additive serotonergic effects.
What to do
Avoid the combination where possible and choose a different antiemetic. If used, monitor blood pressure and for serotonin toxicity or extrapyramidal signs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Isocarboxazid and Metoclopramide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
References
Other interactions of Metoclopramide
Other interactions of Isocarboxazid
- 5-HTP + Isocarboxazid Contraindicated
- Amitriptyline + Isocarboxazid Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amoxapine + Isocarboxazid Contraindicated
- Apraclonidine + Isocarboxazid Contraindicated
- Atomoxetine + Isocarboxazid Contraindicated
Frequently asked questions
Can I take Isocarboxazid with Metoclopramide?
MediHelp rates the interaction as major. Isocarboxazid and Metoclopramide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Metoclopramide has been reported to release catecholamines and may provoke a pressor response, which could be exaggerated in patients taking MAO inhibitors. Combined serotonergic and dopaminergic effects may also add risk of neurological toxicity.
How serious is the interaction between Isocarboxazid and Metoclopramide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and choose a different antiemetic. If used, monitor blood pressure and for serotonin toxicity or extrapyramidal signs.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
