Drug interactions
Isoflurane + Leuprolide
Severity: Minor
Isoflurane and Leuprolide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Leuprolide, as androgen deprivation therapy, can prolong the QT interval slightly, and volatile anesthetics may add to this. The effect is usually small.
What this interaction means in plain words
Isoflurane and Leuprolide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Isoflurane belongs to Central Nervous System; Leuprolide belongs to Endocrine.
Why it happens
Possible additive QT prolongation.
What to do
Consider a baseline ECG in patients with other QT risk factors and keep electrolytes normal.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Isoflurane
Other interactions of Leuprolide
- Leuprolide + Pimozide Contraindicated
- Leuprolide + Thioridazine Contraindicated
- Amisulpride + Leuprolide Major
- Arsenic trioxide + Leuprolide Major
- Artemether / lumefantrine + Leuprolide Major
- Disopyramide + Leuprolide Major
Frequently asked questions
Can I take Isoflurane with Leuprolide?
MediHelp rates the interaction as minor. Isoflurane and Leuprolide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Leuprolide, as androgen deprivation therapy, can prolong the QT interval slightly, and volatile anesthetics may add to this. The effect is usually small.
How serious is the interaction between Isoflurane and Leuprolide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a baseline ECG in patients with other QT risk factors and keep electrolytes normal.
What other medicines interact with Isoflurane?
MediHelp also lists interactions of Isoflurane with, for example, Adrenaline-articaine, Amisulpride, Arsenic trioxide. The full list is on the Isoflurane page.
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