Drug interactions
Isoflurane + Metoclopramide
Severity: Minor
Isoflurane and Metoclopramide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoclopramide is commonly used perioperatively and is generally compatible with volatile anaesthetics. It may modestly reduce anaesthetic requirements through additive CNS effects, but no important adverse interaction is established.
What this interaction means in plain words
Isoflurane and Metoclopramide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Isoflurane belongs to Central Nervous System; Metoclopramide belongs to Gastrointestinal Tract.
Why it happens
Possible mild additive CNS depression; no established significant mechanism.
What to do
No specific action is required; monitor anaesthetic depth as usual.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metoclopramide
Other interactions of Isoflurane
Frequently asked questions
Can I take Isoflurane with Metoclopramide?
MediHelp rates the interaction as minor. Isoflurane and Metoclopramide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Metoclopramide is commonly used perioperatively and is generally compatible with volatile anaesthetics. It may modestly reduce anaesthetic requirements through additive CNS effects, but no important adverse interaction is established.
How serious is the interaction between Isoflurane and Metoclopramide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is required; monitor anaesthetic depth as usual.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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