Drug interactions
Isoflurane + Posaconazole
Severity: Moderate
Isoflurane and Posaconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoflurane can prolong the QT interval, and posaconazole has a similar effect. The combination may increase perioperative arrhythmia risk, particularly with electrolyte disturbances.
What this interaction means in plain words
Isoflurane and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isoflurane belongs to Central Nervous System; Posaconazole belongs to Anti Fungals.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Check a preoperative ECG and correct potassium and magnesium. Use continuous ECG monitoring during anesthesia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Isoflurane
Frequently asked questions
Can I take Isoflurane with Posaconazole?
MediHelp rates the interaction as moderate. Isoflurane and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isoflurane can prolong the QT interval, and posaconazole has a similar effect. The combination may increase perioperative arrhythmia risk, particularly with electrolyte disturbances.
How serious is the interaction between Isoflurane and Posaconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a preoperative ECG and correct potassium and magnesium. Use continuous ECG monitoring during anesthesia.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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