Drug interactions
Isoflurane + Prochlorperazine
Severity: Moderate
Isoflurane and Prochlorperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoflurane can prolong the QT interval and prochlorperazine adds similar potential, increasing arrhythmia risk perioperatively. Phenothiazines also add to hypotension and anesthetic CNS depression.
What this interaction means in plain words
Isoflurane and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isoflurane belongs to Central Nervous System; Prochlorperazine belongs to Central Nervous System.
Why it happens
Additive QT prolongation, with additive CNS depression and vasodilation.
What to do
Review ECG and electrolytes before anesthesia in at-risk patients. Monitor blood pressure and rhythm intraoperatively.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Other interactions of Isoflurane
Frequently asked questions
Can I take Isoflurane with Prochlorperazine?
MediHelp rates the interaction as moderate. Isoflurane and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isoflurane can prolong the QT interval and prochlorperazine adds similar potential, increasing arrhythmia risk perioperatively. Phenothiazines also add to hypotension and anesthetic CNS depression.
How serious is the interaction between Isoflurane and Prochlorperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Review ECG and electrolytes before anesthesia in at-risk patients. Monitor blood pressure and rhythm intraoperatively.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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