Drug interactions
Isoproterenol + Opicapone
Severity: Moderate
Isoproterenol and Opicapone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoproterenol is partly metabolized by catechol-O-methyltransferase, and opicapone inhibits this enzyme. Exposure to isoproterenol may rise, causing excessive tachycardia, arrhythmia or blood pressure changes.
What this interaction means in plain words
Isoproterenol and Opicapone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isoproterenol belongs to Respiratory; Opicapone belongs to Central Nervous System.
Why it happens
Opicapone inhibits COMT, reducing the O-methylation clearance of isoproterenol.
What to do
Monitor heart rate, rhythm and blood pressure and start isoproterenol at a low dose with careful titration. Consider an alternative if tachyarrhythmias occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoproterenol
Other interactions of Opicapone
- Isocarboxazid + Opicapone Contraindicated
- Opicapone + Phenelzine Contraindicated
- Opicapone + Tranylcypromine Contraindicated
- Adrenaline-articaine + Opicapone Moderate
- Asenapine + Opicapone Moderate
- Dobutamine + Opicapone Moderate
Frequently asked questions
Can I take Isoproterenol with Opicapone?
MediHelp rates the interaction as moderate. Isoproterenol and Opicapone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isoproterenol is partly metabolized by catechol-O-methyltransferase, and opicapone inhibits this enzyme. Exposure to isoproterenol may rise, causing excessive tachycardia, arrhythmia or blood pressure changes.
How serious is the interaction between Isoproterenol and Opicapone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, rhythm and blood pressure and start isoproterenol at a low dose with careful titration. Consider an alternative if tachyarrhythmias occur.
What other medicines interact with Isoproterenol?
MediHelp also lists interactions of Isoproterenol with, for example, Adrenaline-articaine, Bisoprolol, Budesonide-formoterol. The full list is on the Isoproterenol page.
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