Drug interactions
Isoproterenol + Ozanimod
Severity: Moderate
Isoproterenol and Ozanimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The active metabolites of ozanimod inhibit MAO-B in vitro, so there is concern about enhanced sympathomimetic effects. Isoproterenol is not a major MAO substrate, so the clinical risk is probably smaller than with indirect sympathomimetics, but blood pressure and heart rate rises are possible.
What this interaction means in plain words
Isoproterenol and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isoproterenol belongs to Respiratory; Ozanimod belongs to Central Nervous System.
Why it happens
Possible MAO inhibition by ozanimod metabolites adds to adrenergic stimulation, though the mechanism is largely theoretical for this direct agonist.
What to do
Monitor blood pressure and heart rate during co-administration. Avoid other agents that raise norepinephrine or serotonin where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoproterenol
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Isoproterenol with Ozanimod?
MediHelp rates the interaction as moderate. Isoproterenol and Ozanimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The active metabolites of ozanimod inhibit MAO-B in vitro, so there is concern about enhanced sympathomimetic effects. Isoproterenol is not a major MAO substrate, so the clinical risk is probably smaller than with indirect sympathomimetics, but blood pressure and heart rate rises are possible.
How serious is the interaction between Isoproterenol and Ozanimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate during co-administration. Avoid other agents that raise norepinephrine or serotonin where possible.
What other medicines interact with Isoproterenol?
MediHelp also lists interactions of Isoproterenol with, for example, Adrenaline-articaine, Bisoprolol, Budesonide-formoterol. The full list is on the Isoproterenol page.
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