Drug interactions
Isoproterenol + Sevoflurane
Severity: Moderate
Isoproterenol and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sevoflurane sensitizes the myocardium to beta-agonists, so isoproterenol may provoke tachyarrhythmias and ventricular ectopy. Hemodynamic swings, including hypotension from vasodilation, can also occur.
What this interaction means in plain words
Isoproterenol and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isoproterenol belongs to Respiratory; Sevoflurane belongs to Central Nervous System.
Why it happens
Anesthetic-induced myocardial sensitization to beta-adrenergic stimulation.
What to do
Titrate isoproterenol slowly to effect, with continuous ECG and blood pressure monitoring. Reduce the dose or stop the infusion if ventricular arrhythmias develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sevoflurane
Other interactions of Isoproterenol
Frequently asked questions
Can I take Isoproterenol with Sevoflurane?
MediHelp rates the interaction as moderate. Isoproterenol and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sevoflurane sensitizes the myocardium to beta-agonists, so isoproterenol may provoke tachyarrhythmias and ventricular ectopy. Hemodynamic swings, including hypotension from vasodilation, can also occur.
How serious is the interaction between Isoproterenol and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate isoproterenol slowly to effect, with continuous ECG and blood pressure monitoring. Reduce the dose or stop the infusion if ventricular arrhythmias develop.
What other medicines interact with Sevoflurane?
MediHelp also lists interactions of Sevoflurane with, for example, Amiodarone, Amisulpride, Arsenic trioxide. The full list is on the Sevoflurane page.
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