Drug interactions
Isoproterenol + Sotalol
Severity: Moderate
Isoproterenol and Sotalol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotalol is a nonselective beta-blocker and directly antagonizes isoproterenol, a pure beta-agonist, reducing its effect on heart rate and bronchial or vascular tone. Isoproterenol can also lower potassium and provoke arrhythmias in a patient taking a QT-prolonging drug.
What this interaction means in plain words
Isoproterenol and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isoproterenol belongs to Respiratory; Sotalol belongs to Cardiovascular.
Why it happens
Competitive pharmacodynamic antagonism at beta-adrenergic receptors; isoproterenol-related hypokalemia may add to sotalol proarrhythmic risk.
What to do
Monitor heart rate, blood pressure, ECG and potassium, and expect to need higher isoproterenol doses. Use an alternative chronotrope if the response is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Other interactions of Isoproterenol
Frequently asked questions
Can I take Isoproterenol with Sotalol?
MediHelp rates the interaction as moderate. Isoproterenol and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sotalol is a nonselective beta-blocker and directly antagonizes isoproterenol, a pure beta-agonist, reducing its effect on heart rate and bronchial or vascular tone. Isoproterenol can also lower potassium and provoke arrhythmias in a patient taking a QT-prolonging drug.
How serious is the interaction between Isoproterenol and Sotalol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure, ECG and potassium, and expect to need higher isoproterenol doses. Use an alternative chronotrope if the response is inadequate.
What other medicines interact with Sotalol?
MediHelp also lists interactions of Sotalol with, for example, Arsenic trioxide, Artemether / lumefantrine, Disopyramide. The full list is on the Sotalol page.
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