Drug interactions
Isoproterenol + Tiotropium-olodaterol
Severity: Major
Isoproterenol and Tiotropium-olodaterol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoproterenol is a non-selective beta agonist and combined with olodaterol it produces additive adrenergic effects including tachycardia, hypertension, tremor, arrhythmias and hypokalemia. The combination offers no benefit and increases cardiac risk.
What this interaction means in plain words
Isoproterenol and Tiotropium-olodaterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Isoproterenol belongs to Respiratory; Tiotropium-olodaterol belongs to Respiratory.
Why it happens
Additive beta-adrenergic receptor stimulation.
What to do
Avoid concurrent use of other beta agonists with olodaterol where possible. If isoproterenol is needed, monitor ECG, heart rate, blood pressure and potassium closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Tiotropium-olodaterol
Other interactions of Isoproterenol
Frequently asked questions
Can I take Isoproterenol with Tiotropium-olodaterol?
MediHelp rates the interaction as major. Isoproterenol and Tiotropium-olodaterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Isoproterenol is a non-selective beta agonist and combined with olodaterol it produces additive adrenergic effects including tachycardia, hypertension, tremor, arrhythmias and hypokalemia. The combination offers no benefit and increases cardiac risk.
How serious is the interaction between Isoproterenol and Tiotropium-olodaterol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of other beta agonists with olodaterol where possible. If isoproterenol is needed, monitor ECG, heart rate, blood pressure and potassium closely.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
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