Drug interactions
Isoproterenol + Trazodone
Severity: Moderate
Isoproterenol and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trazodone's alpha-blocking activity may modify cardiovascular responses to isoproterenol, which can cause tachycardia and hypotension. The effect is unpredictable.
What this interaction means in plain words
Isoproterenol and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isoproterenol belongs to Respiratory; Trazodone belongs to Central Nervous System.
Why it happens
Alpha-1 adrenergic blockade by trazodone alters hemodynamic response to a beta-agonist; the interaction is poorly characterized.
What to do
Monitor heart rate, rhythm and blood pressure during isoproterenol use and titrate to response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Other interactions of Isoproterenol
Frequently asked questions
Can I take Isoproterenol with Trazodone?
MediHelp rates the interaction as moderate. Isoproterenol and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trazodone's alpha-blocking activity may modify cardiovascular responses to isoproterenol, which can cause tachycardia and hypotension. The effect is unpredictable.
How serious is the interaction between Isoproterenol and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, rhythm and blood pressure during isoproterenol use and titrate to response.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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