Drug interactions
Isoproterenol + Trimipramine
Severity: Moderate
Isoproterenol and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclics can alter responses to direct sympathomimetics. Isoproterenol is not taken up by the same neuronal mechanism, so the effect is less pronounced than with epinephrine, but additive tachycardia and arrhythmia are still possible.
What this interaction means in plain words
Isoproterenol and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isoproterenol belongs to Respiratory; Trimipramine belongs to Central Nervous System.
Why it happens
Additive adrenergic cardiovascular effects, with some tricyclic modulation of adrenergic responsiveness.
What to do
Monitor heart rate, blood pressure and the ECG when isoproterenol is given to a patient taking trimipramine, and titrate the isoproterenol dose cautiously.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Isoproterenol and Trimipramine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Other interactions of Isoproterenol
Frequently asked questions
Can I take Isoproterenol with Trimipramine?
MediHelp rates the interaction as moderate. Isoproterenol and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tricyclics can alter responses to direct sympathomimetics. Isoproterenol is not taken up by the same neuronal mechanism, so the effect is less pronounced than with epinephrine, but additive tachycardia and arrhythmia are still possible.
How serious is the interaction between Isoproterenol and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and the ECG when isoproterenol is given to a patient taking trimipramine, and titrate the isoproterenol dose cautiously.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
