Drug interactions
Isosorbide dinitrate + Maraviroc
Severity: Moderate
Isosorbide dinitrate and Maraviroc: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Maraviroc can cause postural hypotension, and nitrates are potent vasodilators. Combined use may increase the risk of dizziness, syncope and falls.
What this interaction means in plain words
Isosorbide dinitrate and Maraviroc can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Isosorbide dinitrate belongs to Cardiovascular; Maraviroc belongs to Anti Virals.
Why it happens
Additive blood-pressure-lowering effects (pharmacodynamic).
What to do
Monitor blood pressure and orthostatic symptoms, particularly at initiation or dose changes. Counsel patients to rise slowly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isosorbide dinitrate
- Avanafil + Isosorbide dinitrate Contraindicated
- Isosorbide dinitrate + Riociguat Contraindicated
- Isosorbide dinitrate + Sildenafil Contraindicated
- Isosorbide dinitrate + Tadalafil Contraindicated
- Isosorbide dinitrate + Vardenafil Contraindicated
- Ergotamine + Isosorbide dinitrate Major
Other interactions of Maraviroc
- Amobarbital + Maraviroc Major
- Apalutamide + Maraviroc Major
- Carbamazepine + Maraviroc Major
- Clarithromycin + Maraviroc Major
- Efavirenz + Maraviroc Major
- Enzalutamide + Maraviroc Major
Frequently asked questions
Can I take Isosorbide dinitrate with Maraviroc?
MediHelp rates the interaction as moderate. Isosorbide dinitrate and Maraviroc can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Maraviroc can cause postural hypotension, and nitrates are potent vasodilators. Combined use may increase the risk of dizziness, syncope and falls.
How serious is the interaction between Isosorbide dinitrate and Maraviroc?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms, particularly at initiation or dose changes. Counsel patients to rise slowly.
What other medicines interact with Isosorbide dinitrate?
MediHelp also lists interactions of Isosorbide dinitrate with, for example, Avanafil, Riociguat, Sildenafil. The full list is on the Isosorbide dinitrate page.
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