Drug interactions
Isotretinoin + Tecovirimat
Severity: Minor
Isotretinoin and Tecovirimat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tecovirimat weakly inhibits CYP2C8 and CYP2C19 and may slightly raise isotretinoin exposure. A meaningful clinical effect is unlikely.
What this interaction means in plain words
Isotretinoin and Tecovirimat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Isotretinoin belongs to Dermatology; Tecovirimat belongs to Miscellaneous.
Why it happens
Weak CYP2C8/CYP2C19 inhibition by tecovirimat reduces isotretinoin metabolism.
What to do
No dose change typically needed; monitor for isotretinoin adverse effects during the tecovirimat course.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Isotretinoin
- Demeclocycline + Isotretinoin Contraindicated
- Isotretinoin + Minocycline Contraindicated
- Isotretinoin + Oxytetracycline Contraindicated
- Isotretinoin + Palovarotene Contraindicated
- Aminolevulinic acid + Isotretinoin Major
- Doxycycline + Isotretinoin Major
Other interactions of Tecovirimat
- Bosentan + Tecovirimat Moderate
- Cyclosporin + Tecovirimat Moderate
- Darunavir + Tecovirimat Moderate
- Ethinyl estradiol-drospirenone + Tecovirimat Moderate
- Ethinyl estradiol-levonorgestrel + Tecovirimat Moderate
- Glimepiride-pioglitazone + Tecovirimat Moderate
Frequently asked questions
Can I take Isotretinoin with Tecovirimat?
MediHelp rates the interaction as minor. Isotretinoin and Tecovirimat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tecovirimat weakly inhibits CYP2C8 and CYP2C19 and may slightly raise isotretinoin exposure. A meaningful clinical effect is unlikely.
How serious is the interaction between Isotretinoin and Tecovirimat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change typically needed; monitor for isotretinoin adverse effects during the tecovirimat course.
What other medicines interact with Isotretinoin?
MediHelp also lists interactions of Isotretinoin with, for example, Demeclocycline, Minocycline, Oxytetracycline. The full list is on the Isotretinoin page.
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