Drug interactions
Isotretinoin + Tizanidine
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Potential additive hepatotoxicity; both agents can elevate transaminases and rarely cause liver injury.
Mechanism of action
Pharmacodynamic: combined exposure to two hepatotoxic agents increases risk of liver enzyme elevations or injury.
Clinical management
Avoid in significant baseline hepatic impairment. Obtain baseline and periodic LFTs; increase monitoring frequency if abnormalities emerge. Interrupt or discontinue if ALT/AST >3× ULN or if clinical hepatitis develops.
Drug reference
References
- Isotretinoin Capsules Prescribing Information – Warnings: Hepatotoxicity — FDA Label
- Tizanidine Prescribing Information – Warnings and Precautions: Hepatotoxicity — FDA Label
- Tizanidine: Drug Information (monograph) — Lexicomp
Frequently asked questions
Can I take Isotretinoin with Tizanidine?
The interaction is rated: Moderate. Potential additive hepatotoxicity; both agents can elevate transaminases and rarely cause liver injury.
How serious is the interaction between Isotretinoin and Tizanidine?
The interaction is rated: Moderate. Evidence level: Moderate.
How is the interaction between Isotretinoin and Tizanidine managed?
Avoid in significant baseline hepatic impairment. Obtain baseline and periodic LFTs; increase monitoring frequency if abnormalities emerge. Interrupt or discontinue if ALT/AST >3× ULN or if clinical hepatitis develops.
Why do Isotretinoin and Tizanidine interact?
Pharmacodynamic: combined exposure to two hepatotoxic agents increases risk of liver enzyme elevations or injury.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.