Drug interactions
Istradefylline + Ivermectin
Severity: Minor
Istradefylline and Ivermectin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Istradefylline at higher doses inhibits P-glycoprotein and raised exposure to P-gp substrates in clinical studies. Ivermectin exposure may rise, though the safety margin of ivermectin makes significant harm unlikely.
What this interaction means in plain words
Istradefylline and Ivermectin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Istradefylline belongs to Central Nervous System; Ivermectin belongs to Anti Parasitic.
Why it happens
Istradefylline inhibits P-glycoprotein, decreasing ivermectin efflux.
What to do
No dose change is typically needed. Monitor for increased adverse effects of ivermectin such as dizziness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ivermectin
- Erdafitinib + Ivermectin Moderate
- Ivermectin + Lasmiditan Moderate
- Ivermectin + Quinidine Moderate
- Ivermectin + Rifampin Moderate
- Ivermectin + Sotorasib Moderate
- Ivermectin + Tepotinib Moderate
Other interactions of Istradefylline
Frequently asked questions
Can I take Istradefylline with Ivermectin?
MediHelp rates the interaction as minor. Istradefylline and Ivermectin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Istradefylline at higher doses inhibits P-glycoprotein and raised exposure to P-gp substrates in clinical studies. Ivermectin exposure may rise, though the safety margin of ivermectin makes significant harm unlikely.
How serious is the interaction between Istradefylline and Ivermectin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is typically needed. Monitor for increased adverse effects of ivermectin such as dizziness.
What other medicines interact with Ivermectin?
MediHelp also lists interactions of Ivermectin with, for example, Erdafitinib, Lasmiditan, Quinidine. The full list is on the Ivermectin page.
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