Drug interactions
Istradefylline + Medroxyprogesterone
Severity: Minor
Istradefylline and Medroxyprogesterone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
At 40 mg daily istradefylline weakly inhibits CYP3A4 and may raise exposure to CYP3A4 substrates such as medroxyprogesterone. The effect is expected to be small and was not seen at 20 mg daily.
What this interaction means in plain words
Istradefylline and Medroxyprogesterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Istradefylline belongs to Central Nervous System; Medroxyprogesterone belongs to Endocrine.
Why it happens
Dose-dependent weak CYP3A4 inhibition by istradefylline.
What to do
No routine adjustment is needed; monitor for progestogenic adverse effects if istradefylline 40 mg daily is used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Medroxyprogesterone
Other interactions of Istradefylline
Frequently asked questions
Can I take Istradefylline with Medroxyprogesterone?
MediHelp rates the interaction as minor. Istradefylline and Medroxyprogesterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. At 40 mg daily istradefylline weakly inhibits CYP3A4 and may raise exposure to CYP3A4 substrates such as medroxyprogesterone. The effect is expected to be small and was not seen at 20 mg daily.
How serious is the interaction between Istradefylline and Medroxyprogesterone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor for progestogenic adverse effects if istradefylline 40 mg daily is used.
What other medicines interact with Medroxyprogesterone?
MediHelp also lists interactions of Medroxyprogesterone with, for example, Bosentan, Brigatinib, Eslicarbazepine. The full list is on the Medroxyprogesterone page.
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