Drug interactions
Istradefylline + Montelukast
Severity: Minor
Istradefylline and Montelukast: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Istradefylline at 40 mg/day raises exposure to CYP3A4 substrates, but montelukast relies mainly on CYP2C8 and has a wide therapeutic margin. Any increase is unlikely to be clinically significant.
What this interaction means in plain words
Istradefylline and Montelukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Istradefylline belongs to Central Nervous System; Montelukast belongs to Respiratory.
Why it happens
Istradefylline inhibits CYP3A4, which only partially contributes to montelukast clearance.
What to do
No dose adjustment is needed. Monitor for montelukast adverse effects if the istradefylline dose is high.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Montelukast
- Apalutamide + Montelukast Moderate
- Carbamazepine + Montelukast Moderate
- Deferasirox + Montelukast Moderate
- Enzalutamide + Montelukast Moderate
- Fosphenytoin + Montelukast Moderate
- Gemfibrozil + Montelukast Moderate
Other interactions of Istradefylline
Frequently asked questions
Can I take Istradefylline with Montelukast?
MediHelp rates the interaction as minor. Istradefylline and Montelukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Istradefylline at 40 mg/day raises exposure to CYP3A4 substrates, but montelukast relies mainly on CYP2C8 and has a wide therapeutic margin. Any increase is unlikely to be clinically significant.
How serious is the interaction between Istradefylline and Montelukast?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Monitor for montelukast adverse effects if the istradefylline dose is high.
What other medicines interact with Montelukast?
MediHelp also lists interactions of Montelukast with, for example, Apalutamide, Carbamazepine, Deferasirox. The full list is on the Montelukast page.
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