Drug interactions
Istradefylline + Posaconazole
Severity: Moderate
Istradefylline and Posaconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole raises istradefylline exposure, which may worsen dyskinesia and other dopaminergic adverse effects. Istradefylline may also modestly increase concentrations of P-gp substrates such as posaconazole.
What this interaction means in plain words
Istradefylline and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Istradefylline belongs to Central Nervous System; Posaconazole belongs to Anti Fungals.
Why it happens
Posaconazole inhibits CYP3A4 metabolism of istradefylline, and istradefylline may inhibit P-gp.
What to do
Limit istradefylline to 20 mg daily while taking posaconazole. Monitor for dyskinesia, hallucinations and posaconazole adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Istradefylline
Frequently asked questions
Can I take Istradefylline with Posaconazole?
MediHelp rates the interaction as moderate. Istradefylline and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Posaconazole raises istradefylline exposure, which may worsen dyskinesia and other dopaminergic adverse effects. Istradefylline may also modestly increase concentrations of P-gp substrates such as posaconazole.
How serious is the interaction between Istradefylline and Posaconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit istradefylline to 20 mg daily while taking posaconazole. Monitor for dyskinesia, hallucinations and posaconazole adverse effects.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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