Drug interactions
Istradefylline + Progesterone
Severity: Minor
Istradefylline and Progesterone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Istradefylline at the higher 40 mg/day dose inhibits CYP3A4 and may increase progesterone exposure. This may amplify progestogenic effects.
What this interaction means in plain words
Istradefylline and Progesterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Istradefylline belongs to Central Nervous System; Progesterone belongs to Endocrine.
Why it happens
Istradefylline inhibits CYP3A4 at higher doses, reducing progesterone metabolism.
What to do
Monitor for progestogenic adverse effects if istradefylline 40 mg/day is used; dose reduction of progesterone is rarely needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Progesterone
Other interactions of Istradefylline
Frequently asked questions
Can I take Istradefylline with Progesterone?
MediHelp rates the interaction as minor. Istradefylline and Progesterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Istradefylline at the higher 40 mg/day dose inhibits CYP3A4 and may increase progesterone exposure. This may amplify progestogenic effects.
How serious is the interaction between Istradefylline and Progesterone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for progestogenic adverse effects if istradefylline 40 mg/day is used; dose reduction of progesterone is rarely needed.
What other medicines interact with Progesterone?
MediHelp also lists interactions of Progesterone with, for example, Apalutamide, Carbamazepine, Enzalutamide. The full list is on the Progesterone page.
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