Drug interactions
Itraconazole + Ivacaftor
Severity: Moderate
Itraconazole and Ivacaftor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole substantially increases ivacaftor exposure, which may increase adverse effects such as elevated transaminases, headache and dizziness.
What this interaction means in plain words
Itraconazole and Ivacaftor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Itraconazole belongs to Anti Fungals; Ivacaftor belongs to Miscellaneous.
Why it happens
Strong inhibition of CYP3A4-mediated ivacaftor metabolism.
What to do
Reduce the ivacaftor dose, for example to twice weekly or once daily depending on the product, as directed by labeling. Monitor liver enzymes and clinical tolerability.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Ivacaftor
- Ensitrelvir + Ivacaftor Contraindicated
- Apalutamide + Ivacaftor Major
- Carbamazepine + Ivacaftor Major
- Clarithromycin + Ivacaftor Major
- Efavirenz + Ivacaftor Major
- Enzalutamide + Ivacaftor Major
Frequently asked questions
Can I take Itraconazole with Ivacaftor?
MediHelp rates the interaction as moderate. Itraconazole and Ivacaftor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Itraconazole substantially increases ivacaftor exposure, which may increase adverse effects such as elevated transaminases, headache and dizziness.
How serious is the interaction between Itraconazole and Ivacaftor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the ivacaftor dose, for example to twice weekly or once daily depending on the product, as directed by labeling. Monitor liver enzymes and clinical tolerability.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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