Drug interactions
Itraconazole + Levomilnacipran
Severity: Moderate
Itraconazole and Levomilnacipran: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole raises levomilnacipran exposure, increasing the risk of dose-related adverse effects such as nausea, hypertension, tachycardia, and serotonergic effects.
What this interaction means in plain words
Itraconazole and Levomilnacipran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Itraconazole belongs to Anti Fungals; Levomilnacipran belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4-mediated levomilnacipran metabolism.
What to do
Do not exceed 80 mg/day of levomilnacipran while on a strong CYP3A4 inhibitor. Monitor blood pressure, heart rate and tolerability.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Levomilnacipran
- Isocarboxazid + Levomilnacipran Contraindicated
- Levomilnacipran + Linezolid Contraindicated
- Levomilnacipran + Methylthioninium chloride Contraindicated
- Levomilnacipran + Phenelzine Contraindicated
- Levomilnacipran + Procarbazine Contraindicated
- Levomilnacipran + Rasagiline Contraindicated
Frequently asked questions
Can I take Itraconazole with Levomilnacipran?
MediHelp rates the interaction as moderate. Itraconazole and Levomilnacipran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Itraconazole raises levomilnacipran exposure, increasing the risk of dose-related adverse effects such as nausea, hypertension, tachycardia, and serotonergic effects.
How serious is the interaction between Itraconazole and Levomilnacipran?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not exceed 80 mg/day of levomilnacipran while on a strong CYP3A4 inhibitor. Monitor blood pressure, heart rate and tolerability.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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