Drug interactions
Itraconazole + Losartan
Severity: Minor
Itraconazole and Losartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole may reduce conversion of losartan to its more potent active metabolite E-3174. This could lessen the antihypertensive effect, although the clinical importance is not well established.
What this interaction means in plain words
Itraconazole and Losartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Itraconazole belongs to Anti Fungals; Losartan belongs to Cardiovascular.
Why it happens
Itraconazole inhibits CYP3A4 (and possibly CYP2C9) involved in losartan activation.
What to do
Monitor blood pressure after starting or stopping itraconazole and adjust the losartan dose if control is lost.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Frequently asked questions
Can I take Itraconazole with Losartan?
MediHelp rates the interaction as minor. Itraconazole and Losartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Itraconazole may reduce conversion of losartan to its more potent active metabolite E-3174. This could lessen the antihypertensive effect, although the clinical importance is not well established.
How serious is the interaction between Itraconazole and Losartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure after starting or stopping itraconazole and adjust the losartan dose if control is lost.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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