Drug interactions
itraconazole + lovastatin
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Severe myopathy/rhabdomyolysis from ↑ statin exposure.
Mechanism of action
Strong CYP3A4 inhibition.
Clinical management
Avoid; switch statin or antifungal.
Drug reference
References
- Lovastatin – Label — FDA Label
- Azoles and statins — SPS
- Itraconazole–statin rhabdomyolysis — PubMed
Frequently asked questions
Can I take itraconazole with lovastatin?
The interaction is rated: Contraindicated. Severe myopathy/rhabdomyolysis from ↑ statin exposure.
How serious is the interaction between itraconazole and lovastatin?
The interaction is rated: Contraindicated. Evidence level: High.
How is the interaction between itraconazole and lovastatin managed?
Avoid; switch statin or antifungal.
Why do itraconazole and lovastatin interact?
Strong CYP3A4 inhibition.
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