Drug interactions
Itraconazole + Macimorelin
Severity: Moderate
Itraconazole and Macimorelin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Macimorelin can prolong the QT interval, and itraconazole adds to this effect. Combined use is a concern in a diagnostic setting where it can be avoided.
What this interaction means in plain words
Itraconazole and Macimorelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Itraconazole belongs to Anti Fungals; Macimorelin belongs to Endocrine.
Why it happens
Additive pharmacodynamic QT interval prolongation.
What to do
Avoid giving macimorelin during itraconazole therapy where feasible, or postpone the test. If testing is necessary, check ECG and electrolytes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Macimorelin
Frequently asked questions
Can I take Itraconazole with Macimorelin?
MediHelp rates the interaction as moderate. Itraconazole and Macimorelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Macimorelin can prolong the QT interval, and itraconazole adds to this effect. Combined use is a concern in a diagnostic setting where it can be avoided.
How serious is the interaction between Itraconazole and Macimorelin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving macimorelin during itraconazole therapy where feasible, or postpone the test. If testing is necessary, check ECG and electrolytes.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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