Drug interactions
Itraconazole + Osimertinib
Severity: Moderate
Itraconazole and Osimertinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QTc interval, so combined use may add to the risk of torsades de pointes. Itraconazole may also modestly raise osimertinib levels.
What this interaction means in plain words
Itraconazole and Osimertinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Itraconazole belongs to Anti Fungals; Osimertinib belongs to Oncology.
Why it happens
Additive QT prolongation; minor CYP3A4-mediated pharmacokinetic effect.
What to do
Obtain a baseline ECG and monitor ECG and electrolytes periodically, correcting potassium and magnesium. Consider an alternative antifungal if the QTc becomes prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Osimertinib
Frequently asked questions
Can I take Itraconazole with Osimertinib?
MediHelp rates the interaction as moderate. Itraconazole and Osimertinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QTc interval, so combined use may add to the risk of torsades de pointes. Itraconazole may also modestly raise osimertinib levels.
How serious is the interaction between Itraconazole and Osimertinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor ECG and electrolytes periodically, correcting potassium and magnesium. Consider an alternative antifungal if the QTc becomes prolonged.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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