Drug interactions
Itraconazole + Ospemifene
Severity: Moderate
Itraconazole and Ospemifene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ospemifene is metabolized by CYP3A4 and CYP2C9, and itraconazole can increase its exposure. Higher levels may increase estrogen agonist effects on the endometrium and thromboembolic risk.
What this interaction means in plain words
Itraconazole and Ospemifene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Itraconazole belongs to Anti Fungals; Ospemifene belongs to Endocrine.
Why it happens
CYP3A4 inhibition reduces ospemifene clearance.
What to do
Monitor for adverse effects such as hot flashes, vaginal bleeding and thromboembolism. Consider an alternative therapy if prolonged itraconazole treatment is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Ospemifene
- Bazedoxifene-conjugated estrogens + Ospemifene Contraindicated
- Estradiol + Ospemifene Contraindicated
- Clomiphene + Ospemifene Major
- Fluconazole + Ospemifene Major
- Ketoconazole + Ospemifene Major
- Ospemifene + Raloxifene Major
Frequently asked questions
Can I take Itraconazole with Ospemifene?
MediHelp rates the interaction as moderate. Itraconazole and Ospemifene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ospemifene is metabolized by CYP3A4 and CYP2C9, and itraconazole can increase its exposure. Higher levels may increase estrogen agonist effects on the endometrium and thromboembolic risk.
How serious is the interaction between Itraconazole and Ospemifene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for adverse effects such as hot flashes, vaginal bleeding and thromboembolism. Consider an alternative therapy if prolonged itraconazole treatment is needed.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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