Drug interactions
Itraconazole + Paliperidone
Severity: Moderate
Itraconazole and Paliperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QTc interval, and itraconazole through P-glycoprotein inhibition may raise paliperidone exposure. This could increase the chance of QT-related arrhythmia and adverse effects.
What this interaction means in plain words
Itraconazole and Paliperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Itraconazole belongs to Anti Fungals; Paliperidone belongs to Central Nervous System.
Why it happens
Additive QT prolongation plus P-glycoprotein inhibition by itraconazole increasing paliperidone absorption and reducing renal and gut efflux; CYP3A4 plays only a minor role.
What to do
Monitor ECG and electrolytes, and consider a paliperidone dose reduction if adverse effects occur. Avoid additional QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Paliperidone
- Ibutilide + Paliperidone Contraindicated
- Paliperidone + Pimozide Contraindicated
- Paliperidone + Vandetanib Contraindicated
- Adagrasib + Paliperidone Major
- Amiodarone + Paliperidone Major
- Amisulpride + Paliperidone Major
Frequently asked questions
Can I take Itraconazole with Paliperidone?
MediHelp rates the interaction as moderate. Itraconazole and Paliperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QTc interval, and itraconazole through P-glycoprotein inhibition may raise paliperidone exposure. This could increase the chance of QT-related arrhythmia and adverse effects.
How serious is the interaction between Itraconazole and Paliperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes, and consider a paliperidone dose reduction if adverse effects occur. Avoid additional QT-prolonging drugs.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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