Drug interactions
Itraconazole + Perphenazine
Severity: Moderate
Itraconazole and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so co-administration may raise the risk of torsades de pointes. Itraconazole may also raise perphenazine levels through metabolic inhibition.
What this interaction means in plain words
Itraconazole and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Itraconazole belongs to Anti Fungals; Perphenazine belongs to Central Nervous System.
Why it happens
Additive QT prolongation, with possible inhibition of perphenazine metabolism by itraconazole.
What to do
Obtain a baseline ECG and correct electrolyte disturbances. Monitor QTc and for extrapyramidal or sedative effects, and consider an alternative antifungal in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Itraconazole with Perphenazine?
MediHelp rates the interaction as moderate. Itraconazole and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, so co-administration may raise the risk of torsades de pointes. Itraconazole may also raise perphenazine levels through metabolic inhibition.
How serious is the interaction between Itraconazole and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct electrolyte disturbances. Monitor QTc and for extrapyramidal or sedative effects, and consider an alternative antifungal in high-risk patients.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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