Drug interactions
Itraconazole + Rilpivirine
Severity: Moderate
Itraconazole and Rilpivirine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole increases rilpivirine exposure, and both drugs have QT-prolonging potential, mainly at supratherapeutic rilpivirine levels. Rilpivirine may also modestly lower itraconazole exposure.
What this interaction means in plain words
Itraconazole and Rilpivirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Itraconazole belongs to Anti Fungals; Rilpivirine belongs to Anti Virals.
Why it happens
CYP3A4 inhibition raises rilpivirine levels, with possible additive QT effects.
What to do
No rilpivirine dose adjustment is needed. Monitor for breakthrough fungal infection and consider an ECG if other QT-prolonging risk factors are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Rilpivirine
- Carbamazepine + Rilpivirine Contraindicated
- Dexamethasone + Rilpivirine Contraindicated
- Dexlansoprazole + Rilpivirine Contraindicated
- Efavirenz + Rilpivirine Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Esomeprazole + Rilpivirine Contraindicated
Frequently asked questions
Can I take Itraconazole with Rilpivirine?
MediHelp rates the interaction as moderate. Itraconazole and Rilpivirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Itraconazole increases rilpivirine exposure, and both drugs have QT-prolonging potential, mainly at supratherapeutic rilpivirine levels. Rilpivirine may also modestly lower itraconazole exposure.
How serious is the interaction between Itraconazole and Rilpivirine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No rilpivirine dose adjustment is needed. Monitor for breakthrough fungal infection and consider an ECG if other QT-prolonging risk factors are present.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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