Drug interactions
Itraconazole + Rimegepant
Severity: Major
Itraconazole and Rimegepant: major interaction.
Last updated Sources: EMA SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole increases rimegepant exposure, which may enhance adverse effects. The labeling advises against this combination.
What this interaction means in plain words
Itraconazole and Rimegepant can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Itraconazole belongs to Anti Fungals; Rimegepant belongs to Central Nervous System.
Why it happens
Itraconazole inhibits CYP3A4 and P-glycoprotein, both involved in rimegepant clearance.
What to do
Avoid concomitant use of rimegepant with strong CYP3A4 inhibitors. If an antifungal is needed, choose one without strong CYP3A4 inhibition.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Rimegepant
Frequently asked questions
Can I take Itraconazole with Rimegepant?
MediHelp rates the interaction as major. Itraconazole and Rimegepant can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Itraconazole increases rimegepant exposure, which may enhance adverse effects. The labeling advises against this combination.
How serious is the interaction between Itraconazole and Rimegepant?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use of rimegepant with strong CYP3A4 inhibitors. If an antifungal is needed, choose one without strong CYP3A4 inhibition.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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