Drug interactions
Itraconazole + Ripretinib
Severity: Moderate
Itraconazole and Ripretinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole increases exposure to ripretinib and its active metabolite, which may increase adverse reactions such as palmar-plantar erythrodysesthesia, hypertension and fatigue.
What this interaction means in plain words
Itraconazole and Ripretinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Itraconazole belongs to Anti Fungals; Ripretinib belongs to Oncology.
Why it happens
Strong CYP3A4 inhibition reduces the metabolism of ripretinib and its active metabolite.
What to do
Monitor for ripretinib toxicity and manage adverse reactions by interruption or dose reduction. Prefer a weaker CYP3A inhibitor if an antifungal is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Ripretinib
- Amobarbital + Ripretinib Major
- Apalutamide + Ripretinib Major
- Carbamazepine + Ripretinib Major
- Efavirenz + Ripretinib Major
- Enzalutamide + Ripretinib Major
- Phenytoin + Ripretinib Major
Frequently asked questions
Can I take Itraconazole with Ripretinib?
MediHelp rates the interaction as moderate. Itraconazole and Ripretinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Itraconazole increases exposure to ripretinib and its active metabolite, which may increase adverse reactions such as palmar-plantar erythrodysesthesia, hypertension and fatigue.
How serious is the interaction between Itraconazole and Ripretinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for ripretinib toxicity and manage adverse reactions by interruption or dose reduction. Prefer a weaker CYP3A inhibitor if an antifungal is needed.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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