Drug interactions
Itraconazole + Tipranavir
Severity: Major
Itraconazole and Tipranavir: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tipranavir, boosted with ritonavir, strongly affects CYP3A4 and P-gp and can raise itraconazole concentrations, increasing risks of itraconazole toxicity such as heart failure effects, QT effects and hepatotoxicity. Itraconazole may also raise protease inhibitor exposure.
What this interaction means in plain words
Itraconazole and Tipranavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Itraconazole belongs to Anti Fungals; Tipranavir belongs to Anti Virals.
Why it happens
Ritonavir-boosted tipranavir inhibits CYP3A4 metabolism of itraconazole.
What to do
Avoid high itraconazole doses and monitor itraconazole concentrations, liver function and ECG if used together. Consider an alternative antifungal.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Itraconazole with Tipranavir?
MediHelp rates the interaction as major. Itraconazole and Tipranavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tipranavir, boosted with ritonavir, strongly affects CYP3A4 and P-gp and can raise itraconazole concentrations, increasing risks of itraconazole toxicity such as heart failure effects, QT effects and hepatotoxicity. Itraconazole may also raise protease inhibitor exposure.
How serious is the interaction between Itraconazole and Tipranavir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid high itraconazole doses and monitor itraconazole concentrations, liver function and ECG if used together. Consider an alternative antifungal.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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