Drug interactions
Itraconazole + Velpatasvir
Severity: Minor
Itraconazole and Velpatasvir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole may modestly raise velpatasvir concentrations since velpatasvir is partly metabolized by CYP3A4. The effect is likely small and the combination is generally well tolerated.
What this interaction means in plain words
Itraconazole and Velpatasvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Itraconazole belongs to Anti Fungals; Velpatasvir belongs to Anti Virals.
Why it happens
CYP3A4 (and possibly P-gp) inhibition by itraconazole may increase velpatasvir exposure.
What to do
No dose adjustment is needed. Monitor for adverse effects such as headache and fatigue.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Velpatasvir
- Apalutamide + Velpatasvir Contraindicated
- Carbamazepine + Velpatasvir Contraindicated
- Phenytoin + Velpatasvir Contraindicated
- Bosentan + Velpatasvir Major
- Colchicine + Velpatasvir Major
- Efavirenz + Velpatasvir Major
Frequently asked questions
Can I take Itraconazole with Velpatasvir?
MediHelp rates the interaction as minor. Itraconazole and Velpatasvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Itraconazole may modestly raise velpatasvir concentrations since velpatasvir is partly metabolized by CYP3A4. The effect is likely small and the combination is generally well tolerated.
How serious is the interaction between Itraconazole and Velpatasvir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Monitor for adverse effects such as headache and fatigue.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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