Drug interactions
Itraconazole + Vemurafenib
Severity: Major
Itraconazole and Vemurafenib: major interaction.
Last updated Sources: EMA SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vemurafenib can prolong the QT interval and itraconazole adds to this effect. Itraconazole can also raise vemurafenib levels via CYP3A4 inhibition, increasing risks of QT prolongation and other toxicities.
What this interaction means in plain words
Itraconazole and Vemurafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Itraconazole belongs to Anti Fungals; Vemurafenib belongs to Oncology.
Why it happens
Additive QTc prolongation and CYP3A4 inhibition of vemurafenib metabolism.
What to do
Avoid if possible. If unavoidable, monitor ECG and electrolytes and watch for vemurafenib toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Vemurafenib
Frequently asked questions
Can I take Itraconazole with Vemurafenib?
MediHelp rates the interaction as major. Itraconazole and Vemurafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Vemurafenib can prolong the QT interval and itraconazole adds to this effect. Itraconazole can also raise vemurafenib levels via CYP3A4 inhibition, increasing risks of QT prolongation and other toxicities.
How serious is the interaction between Itraconazole and Vemurafenib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible. If unavoidable, monitor ECG and electrolytes and watch for vemurafenib toxicity.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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